Connecting real-time data to humanitarian response tools was a challenging task that had never been done before. Magic Box is a platform using artificial intelligence, Big data and real-time data from both public sources and private sector partners to predict how and where communicable and vector-borne diseases spread and to stop outbreaks before they become epidemics/pandemics. Magic Box has been used to combat Ebola in Sierra Leone and the DRC, and Zika and yellow fever in Latin America.